Anti-AGRN (N-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide from the N terminal residues of Human Agrin protein.

Conjugate

Application Notes

IHC-P: 1/100 - 1/500. Peptide ELISA: 1/10000 - 1/40000.

Alternative Names

AGRN; agrin; AGRIN; agrin proteoglycan; AGRIN; Agrin proteoglycan; AGRN; FLJ45064; OTTHUMP00000044043;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found.

Pathway

Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; NCAM signaling for neurite out-growth, organism-specific biosystem; NCAM1 interactions, organism-specific biosystem;