Anti-AGRN monoclonal antibody, clone Bhs 358

Antibody Isotype

IgG1

Clone

Bhs 358

Species Reactivity

Mouse; Rat

Immunogen

Recombinant rat agrin, C-terminal construct.

Conjugate

Application Notes

ICC: 2 μg/ml.

Alternative Names

AGRN; agrin; AGR;

Entrez Gene ID

UniProt ID

Antigen Description

Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites; increasing the predicted MW from 200kDa to ~600kDa.

Pathway

Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; NCAM signaling for neurite out-growth, organism-specific biosystem; NCAM1 interactions, organism-specific biosystem;