Anti-Heat Shock Protein monoclonal antibody (DMABT-54831MH)

Mouse Anti-Heat Shock Protein monoclonal antibody for IHC, ELISA, IF, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
B740/N8I
Species Reactivity
Turkey, Amphibia, Bovine, Chicken, Human, Mouse, Rabbit, Rat
Immunogen
HSP from turkey gizzard smooth muscle
Conjugate
Unconjugated

Target


Alternative Names
Heat shock proteins

Product Background


Antigen Description
Heat shock proteins (HSP) are a class of functionally related proteins involved in the folding and unfolding of other proteins. Their expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat-shock proteins are named according to their molecular weight. For example, Hsp60, Hsp70 and Hsp90 (the most widely-studied HSPs) refer to families of heat shock proteins on the order of 60, 70, and 90 kilodaltons in size, respectively. The small 8-kilodalton protein ubiquitin, which marks proteins for degradation, also has features of a heat shock protein.

Citations


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References


Cheng, CM; Jain, P; et al. Assessment of the role in protection and pathogenesis of the Chlamydia muridarum V-type ATP synthase subunit A (AtpA) (TC0582). MICROBES AND INFECTION 16:123-133(2014).
Nayak, AP; Green, BJ; et al. Characterization of Cannabis sativa allergens. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 111:32-U56(2013).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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