Anti-Heat Shock Protein monoclonal antibody (DMABT-54831MH)
Mouse Anti-Heat Shock Protein monoclonal antibody for IHC, ELISA, IF, WB
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Turkey, Amphibia, Bovine, Chicken, Human, Mouse, Rabbit, Rat
HSP from turkey gizzard smooth muscle
Heat shock proteins
Heat shock proteins (HSP) are a class of functionally related proteins involved in the folding and unfolding of other proteins. Their expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat-shock proteins are named according to their molecular weight. For example, Hsp60, Hsp70 and Hsp90 (the most widely-studied HSPs) refer to families of heat shock proteins on the order of 60, 70, and 90 kilodaltons in size, respectively. The small 8-kilodalton protein ubiquitin, which marks proteins for degradation, also has features of a heat shock protein.
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Agnew, LL; Colditz, IG; et al. Development of a method of measuring cellular stress in cattle and sheep. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 123:197-204(2008).
Shibata, Y; Ohata, H; et al. Immunologic response enhances atherosclerosis - type 1 helper T cell (Th1)-to-type 2 helper T cell (Th2) shift and calcified atherosclerosis in bacillus Calmette-Guerin (BCG)-treated apolipoprotein E-knockout (apo E-/-) mice. TRANSLATIONAL RESEARCH 149:62-69(2007).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.