This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Pathway
mRNA processing;
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Citations
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Dangli, A; Plomaritoglou, A; et al. Recognition of subsets of the mammalian A/B-type core heterogeneous nuclear ribonucleoprotein polypeptides by novel autoantibodies. BIOCHEMICAL JOURNAL 320:761-767(1996).
MATUNIS, EL; KELLEY, R; et al. ESSENTIAL ROLE FOR A HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN (HNRNP) IN OOGENESIS - HRP40 IS ABSENT FROM THE GERM-LINE IN THE DORSOVENTRAL MUTANT SQUID. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91:2781-2784(1994).
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