Anti-HMGB2 (aa 91-187) polyclonal antibody

Species Reactivity

Human

Immunogen

HMGB2 (NP_002120, 91 a.a. ~ 187 a.a) partial recombinant protein with GST tag. The sequence is DPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAK LKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEP

Conjugate

Alternative Names

HMGB2; high mobility group box 2; HMG2; high mobility group protein B2; HMG-2; high-mobility group box 2; high mobility group protein 2; high-mobility group (nonhistone chromosomal) protein 2;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.

Pathway

Activation of DNA fragmentation factor; Apoptosis induced DNA fragmentation; RB in Cancer;