Anti-HMGA2 (aa 1-92) polyclonal antibody

Species Reactivity

Human

Immunogen

HMGA2 (NP_003474, 1 a.a. ~ 92 a.a) partial recombinant protein with GST tag. The sequence is MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSP SKAAQKKAEATGEKRPRGRPRKWPQQVVQKKP

Conjugate

Alternative Names

HMGA2; high mobility group AT-hook 2; BABL; LIPO; HMGIC; HMGI-C; STQTL9; high mobility group protein HMGI-C; High-mobility group protein HMGI-C; high mobility group AT-hook protein 2; high-mobility group (nonhistone chromosomal) protein isoform I-C;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Pathway

Cellular Senescence; DNA Damage/Telomere Stress Induced Senescence; MicroRNAs in cancer; Transcriptional misregulation in cancer