This gene encodes a protein that belongs to thenon-histone chromosomal high mobility group (HMG) protein family.HMG proteins function as architectural factors and are essentialcomponents of the enhancesome. This protein contains structuralDNA-binding domains and may act as a transcriptional regulatingfactor. Identification of the deletion, amplification, andrearrangement of this gene that are associated with myxoidliposarcoma suggests a role in adipogenesis and mesenchymaldifferentiation. A gene knock out study of the mouse counterpartdemonstrated that this gene is involved in diet-induced obesity.Alternate transcriptional splice variants, encoding differentisoforms, have been characterized.
Pathway
Cellular Senescence; Cellular responses to stress; DNA Damage/Telomere Stress Induced Senescence; Formation of Senescence-Associated Heterochromatin Foci (SAHF); MicroRNAs in cancer; Transcriptional misregulation in cancer
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