Specifications
Immunogen
Synthetic peptide within Human HLA-C aa 65-93 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: P10321
Applications
Application Notes
WB: 1/100 - 1/500;
Target
Alternative Names
HLA-C; major histocompatibility complex, class I, C; HLC-C; D6S204; PSORS1; HLA-JY3; HLA class I histocompatibility antigen, Cw-1 alpha chain; MHC class I antigen heavy chain HLA-C; human leukocyte antigen-C alpha chain; major histocompatibility antigen H
Product Background
Antigen Description
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Pathway
Adaptive Immune System; Allograft rejection; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Antigen processing and presentation
Citations
Publication ()
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COA
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