Anti-HLA-C monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human HLA-C is used for rabbit immunization.

Conjugate

Alternative Names

HLA-C; major histocompatibility complex, class I, C; HLC-C; D6S204; PSORS1; HLA-JY3; HLA class I histocompatibility antigen, Cw-1 alpha chain; MHC class I antigen heavy chain HLA-C; human leukocyte antigen-C alpha chain; major histocompatibility antigen H

Entrez Gene ID

UniProt ID

Antigen Description

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described

Pathway

Adaptive Immune System; Allograft Rejection; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Antigen processing and presentation; Antigen processing-Cross presentation; Autoimmune thyroid disease; Cell adhesion molecules (CAMs); Class I MHC mediated antigen processing &.