Specifications
Immunogen
Recombinant full length Human Hes1 produced in HEK293T cells (NP_005515).
Applications
Application Notes
WB: 1/2000; IHC-P: 1/150; Flow Cyt: 1/100; ICC/IF: 1/100;
Target
Alternative Names
HES1; hairy and enhancer of split 1, (Drosophila); hairy homolog (Drosophila) , HRY; transcription factor HES-1; bHLHb39; FLJ20408; HES 1; Hes1; hairy homolog; hairy-like protein; class B basic helix-loop-helix protein 39; HHL; HRY; HES-1;
Product Background
Antigen Description
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5-CACNAG-3 with high affinity and on E-box motifs: 5-CANNTG-3 with low affinity.
Pathway
ATF-2 transcription factor network, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Id Signaling Pathway, organism-specific biosystem.
Citations
Publication ()
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COA
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