Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation.
Pathway
Activation of Genes by ATF4; Diabetes pathways; Disease; Diurnally regulated genes with circadian orthologs; HRD1/SEL1 ERAD complex; PERK regulated gene expression;
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