Specifications
Immunogen
Recombinant fragment, corresponding to a region within C terminal amino acids 737-952 of Human HDAC7 (Uniprot ID: Q8WUI4).
Applications
Application Notes
WB: 1/500 - 1/3000; ICC/IF: 1/100 - 1/1000; IHC-P: 1/100 - 1/1000.
Target
Alternative Names
HDAC7; histone deacetylase 7; HDAC7A, histone deacetylase 7A; DKFZP586J0917; HD7; histone deacetylase 7A; HD7A; HDAC7A; FLJ99588; DKFZp586J0917;
Product Background
Antigen Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene.
Pathway
B Cell Receptor Signaling Pathway; Cell cycle; HIF-1-alpha transcription factor network; MicroRNAs in cardiomyocyte hypertrophy; NOTCH1 Intracellular Domain Regulates Transcription; Regulation of Androgen receptor activity; Signal Transduction
Citations
Publication ()
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COA
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