Anti-HDAC7 monoclonal antibody, clone IEBD8-08

Antibody Isotype

IgG1

Clone

IEBD8-08

Species Reactivity

Mouse; Human

Immunogen

Synthetic peptide: YRTLEPLDTEGAARSVLSS conjugated to KLH, corresponding to amino acids 137-155 of Mouse HDAC7

Conjugate

Application Notes

WB: 0.25 - 0.5 μg/ml;

Alternative Names

HDAC7; histone deacetylase 7; HD7A; HDAC7A; HD7; histone deacetylase 7A;

Entrez Gene ID

UniProt ID

Antigen Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene.

Pathway

B Cell Receptor Signaling Pathway, organism-specific biosystem; Cell cycle, organism-specific biosystem; MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; T Cell Receptor Signaling Pathway, organism-specific biosystem; estrogen signalling, organism-specific biosystem;