Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Pathway
Alcoholism; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Circadian Clock; Constitutive Signaling by NOTCH1 PEST Domain Mutants
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Q: What is the genetic code for the antigen targeted by the DPAB-DC3665 antibody?
A: Entrez Gene ID: 8841 UniProt ID:O15379
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