Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Pathway
NOTCH1 Intracellular Domain Regulates Transcription; Signal Transduction; Signaling by NOTCH; Signaling by NOTCH1; Signaling events mediated by HDAC Class I; Signaling events mediated by HDAC Class II;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Bradbury, C; Khanim, F; et al. Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. LEUKEMIA 19:1751-1759(2005).
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COA
Certificate of Analysis
