Anti-HCN2 / HCN4 polyclonal antibody (DPABH-17568)

Rabbit anti-Human HCN2 / HCN4 (cytoplasmic domain) polyclonal antibody for WB, IHC-P, IHC-Fr

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse, Rat, Human
Immunogen
A synthetic peptide from the 1t cytoplasmic domain of human HCN2 + HCN4, conjugated to an immunogenic carrier protein. The antigen is homologous in rat and mouse.
Conjugate
Unconjugated

Applications


Application Notes
IHC-P: 1/300 - 1/4000. Antigen retrieval is recommended before commencing with IHC staining protocol. IHC-Fr: 1/300 - 1/4000. WB: 1/300 - 1/4000. Predicted molecular weights: 97 and 129 kDa.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
BCNG2; HAC-1; BCNG-2
Entrez Gene ID
UniProt ID

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Ye, B; Nerbonne, JM; et al. Proteolytic Processing of HCN2 and Co-assembly with HCN4 in the Generation of Cardiac Pacemaker Channels. JOURNAL OF BIOLOGICAL CHEMISTRY 284:25553-25559(2009).
Bolivar, JJ; Tapia, D; et al. A hyperpolarization-activated, cyclic nucleotide-gated, (I-h-like) cationic current and HCN gene expression in renal inner medullary collecting duct cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 294:C893-C906(2008).

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