Anti-HCN2 Cyclic Nucleotide-gated Channel monoclonal antibody (DMAB6741MR)

Mouse anti-Rat HCN2 Cyclic Nucleotide-gated Channel monoclonal antibody for WB, IP, IHC, ICC, IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
T72-38
Species Reactivity
Rat
Conjugate
Unconjugated

Target


Alternative Names
Hcn2; hyperpolarization activated cyclic nucleotide-gated potassium channel 2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; HCN2 Cyclic Nucleotide-gated Channel
Entrez Gene ID
UniProt ID

Product Background


Gene summary
HCN2 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2) is a Protein Coding gene. Diseases associated with HCN2 include sinoatrial node disease. Among its related pathways are Transmission across Chemical Synapses and cAMP signaling pathway. GO annotations related to this gene include identical protein binding and voltage-gated potassium channel activity. An important paralog of this gene is KCNH1. Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.
Antigen Description
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells and their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical
or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand- gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. The first are voltagegated ion channels which open and close in response to membrane potential. These are then seperated into sodium,
calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role.

Citations


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References


Bolivar, JJ; Tapia, D; et al. A hyperpolarization-activated, cyclic nucleotide-gated, (I-h-like) cationic current and HCN gene expression in renal inner medullary collecting duct cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 294:C893-C906(2008).
Mistrik, P; Mader, R; et al. The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides. JOURNAL OF BIOLOGICAL CHEMISTRY 280:27056-27061(2005).

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