Anti-HCK monoclonal antibody, clone 4E23F20

Antibody Isotype

IgG1

Clone

4E23F20

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human HCK.

Conjugate

Application Notes

ELISA (1:10000); WB (1:500-1:2000); Immunohistochemistry (1:200-1:1000) & The optimal working dilution should be determined by the end user.

Alternative Names

HCK; hemopoietic cell kinase; tyrosine-protein kinase HCK; JTK9; p59-HCK/p60-HCK; hematopoietic cell kinase; p59Hck; p61Hck;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.

Pathway

Alpha-synuclein signaling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class I PI3K signaling events, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem.