Anti-HARS2 (aa 2-110) polyclonal antibody

Species Reactivity

Human

Immunogen

HARSL (NP_036340, 2 a.a. ~ 110 a.a) partial recombinant protein with GST tag. The sequence is PLLGLLPRRAWASLLSQLLRPPCASCTGAVRCQSQVAEAVLTSQLKAHQEKPNFIIKTPK GTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGE

Conjugate

Alternative Names

HARS2; histidyl-tRNA synthetase 2, mitochondrial; HO3; HARSL; HARSR; PRLTS2; probable histidine--tRNA ligase, mitochondrial; hisRS; HARS-related; histidine translase; histidine-tRNA ligase homolog; probable histidyl-tRNA synthetase, mitochondrial; histidi

Entrez Gene ID

UniProt ID

Antigen Description

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene.

Pathway

Aminoacyl-tRNA biosynthesis; Gene Expression; tRNA Aminoacylation;