Anti-HAND2 polyclonal antibody (DPAB-DC2627)

Goat anti-Zebrafish HAND2 polyclonal antibody for ELISA Datasheet

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Specifications


Host Species
Goat
Species Reactivity
Zebrafish
Immunogen
A synthetic peptide corresponding to zebrafish hand2. The sequence is C-NDKKTKGRTGWPQH
Conjugate
Unconjugated

Applications


Application Notes
ELISA: 1:32000. & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
HAND2; heart and neural crest derivatives expressed 2; dhand; zdHAND; zgc:103415; heart- and neural crest derivatives-expressed protein 2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
HAND2 (Heart And Neural Crest Derivatives Expressed 2) is a Protein Coding gene. Diseases associated with HAND2 include saethre-chotzen syndrome and heart disease. Among its related pathways are NFAT and Cardiac Hypertrophy and Heart Development. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is LYL1. The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.
Antigen Description
HAND2 (heart and neural crest derivatives expressed 2) is a protein-coding gene. Diseases associated with HAND2 include saethre-chotzen syndrome, and split hand, and among its related super-pathways are Signaling Involved in Cardiac Hypertrophy. GO annotations related to this gene include protein homodimerization activity and transcription factor binding. An important paralog of this gene is NHLH1. Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5-CANNTG-3 (By similarity). Heart- and neural crest derivatives-expressed protein 2 is a protein that in humans is encoded by the HAND2 gene. The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.

Citations


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References


Liu, NM; Yokota, T; et al. Transcription Profiles of Endothelial Cells in the Rat Ductus Arteriosus during a Perinatal Period. PLOS ONE 8:-(2013).

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