General Notes
This product (Catalog No. DPABH-16731) is a rabbit-derived polyclonal antibody raised against human GLI3. This antibody exhibits cross-reactivity with GLI3 from mouse. It has been affinity purified by Protein A. This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.
DPABH-16731 is suitable for use in Western blot (WB) (1:200–1:1,000), IHC (1:20–1:100) applications.
DPABH-16731 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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