Anti-GLI3 monoclonal antibody, clone FQS5605

Antibody Isotype

IgG

Clone

FQS5605

Species Reactivity

Human

Immunogen

Recombinant fragment within Human Gli3 aa 1300-1500. The exact sequence is proprietary.Database link: P10071

Conjugate

Application Notes

ICC/IF: 1/100; WB: 1/1000 - 1/2000.

Alternative Names

GLI3; GLI family zinc finger 3; GCPS, GLI Kruppel family member GLI3 , glioma associated oncogene family zinc finger 3 , Greig cephalopolysyndactyly syndrome , PHS; transcriptional activator GLI3; ACLS; DNA binding protein; oncogene GLI3; PAP A; PAPA;

Entrez Gene ID

UniProt ID

Antigen Description

Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5-GGGTGGTC-3.

Pathway

Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Endochondral Ossification, organism-specific biosystem; Hedgehog Signaling Pathway, organism-specific biosystem; Hedgehog signaling events mediated by Gli proteins, organism-specific biosystem; Hedgehog signaling pathway, organism-specific biosystem; Hedgehog signaling pathway, conserved biosystem;