Anti-GTF2I monoclonal antibody, clone FQS8707

Antibody Isotype

IgG

Clone

FQS8707

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues within Human TFII I.

Conjugate

Application Notes

ICC/IF: 1/100 - 1/250; WB: 1/10000 - 1/50000; IHC-P: 1/50 - 1/100.

Alternative Names

GTF2I; general transcription factor IIi; general transcription factor II, i , WBSCR6; general transcription factor II-I; BAP 135; BTKAP1; DIWS; IB291; SPIN; TFII I; BTK-associated protein 135; BTK-associated protein, 135kD; SRF-Phox1-interacting protein;

Entrez Gene ID

UniProt ID

Antigen Description

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.

Pathway

B Cell Receptor Signaling Pathway, organism-specific biosystem; Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem;