Anti-GTF2I monoclonal antibody (DMABT-H13881)

Mouse anti-Human GTF2I monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
4F3
Species Reactivity
Human
Immunogen
GTF2I (AAH04472.1,47a.a. ~ 274 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
GTF2I; general transcription factor IIi; general transcription factor II, i , WBSCR6; general transcription factor II-I; BAP 135; BTKAP1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GTF2I (General Transcription Factor IIi) is a Protein Coding gene. Diseases associated with GTF2I include williams-beuren syndrome and supravalvar aortic stenosis. Among its related pathways are Akt Signaling and TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and mitogen-activated protein kinase binding. An important paralog of this gene is GTF2IRD1. This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
Antigen Description
Note=GTF2I is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11. 23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of GTF2I may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. General transcription factor II-I is a protein that in humans is encoded by the GTF2I gene. This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11. 23. The exon(s) encoding 5 UTR has not been fully defined, but this gene is known to contain at least 34 exons, and its alternative splicing generates 4 transcript variants. The function about GTF2I antigen include DNA binding; mitogen-activated protein kinase binding; protein binding; sequence-specific DNA binding transcription factor activity.
Pathway
B Cell Receptor Signaling Pathway, organism-specific biosystem; Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem.

Citations


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References


Babel, I; Barderas, R; et al. Identification of MST1/STK4 and SULF1 Proteins as Autoantibody Targets for the Diagnosis of Colorectal Cancer by Using Phage Microarrays. MOLECULAR & CELLULAR PROTEOMICS 10:-(2011).

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