Anti-GSPT2 monoclonal antibody, clone 3H0

Antibody Isotype

IgG1

Clone

3H0

Species Reactivity

Human

Immunogen

Recombinant full length Human eRF3B/GSPT2 produced in HEK293T cells (NP_060564).

Conjugate

Application Notes

WB: 1/2000; Flow Cyt: 1/100; ICC/IF: 1/100;

Alternative Names

GSPT2; G1 to S phase transition 2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B; eRF3b; FLJ10441; eukaryotic peptide chain release factor subunit 3b; GST2; ERF3B;

Entrez Gene ID

UniProt ID

Antigen Description

Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Pathway

Eukaryotic Translation Termination, organism-specific biosystem; Gene Expression, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Nonsense Mediated Decay Enhanced by the Exon Junction Complex, organism-specific biosystem; Nonsense Mediated Decay Independent of the Exon Junction Complex, organism-specific biosystem; Nonsense-Mediated Decay, organism-specific biosystem; Translation, organism-specific biosystem.