Anti-GRM8 (aa 486-575) polyclonal antibody

Species Reactivity

Human

Immunogen

GRM8 (NP_000836, 486 a.a. ~ 575 a.a) partial recombinant protein with GST tag. The sequence is KVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYN YQVDELSCELCPLDQRPNMNRTGCQLIPII

Conjugate

Alternative Names

GRM8; glutamate receptor, metabotropic 8; GLUR8; mGlu8; GPRC1H; MGLUR8; metabotropic glutamate receptor 8;

Entrez Gene ID

UniProt ID

Antigen Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Pathway

Class C/3 (Metabotropic glutamate/pheromone receptors); GPCR downstream signaling; GPCRs, Class C Metabotropic glutamate, pheromone; Glutamatergic synapse