Specifications
Immunogen
A synthetic peptide corresponding to human GRIN2D. The sequence is C-TRRGSAHFSSLESE
Target
Alternative Names
GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; EB11; NR2D; GluN2D; NMDAR2D; glutamate receptor ionotropic, NMDA 2D; estrogen receptor binding CpG island; N-methyl D-aspartate receptor subtype 2D; N-methyl-d-aspartate receptor subunit 2D;
Product Background
Antigen Description
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).
Pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events; Alcoholism; Alzheimers disease; Amphetamine addiction.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Lieberman, R; Levine, ES; et al. Pilot Study of iPS-Derived Neural Cells to Examine Biologic Effects of Alcohol on Human Neurons In Vitro. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 36:1678-1687(2012).
Demontis, D; Nyegaard, M; et al. Association of GRIN1 and GRIN2A-D With Schizophrenia and Genetic Interaction With Maternal Herpes Simplex Virus-2 Infection Affecting Disease Risk. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 156B:913-922(2011).