This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.
Pathway
Activation of Ca-permeable Kainate Receptor; Glutamatergic synapse; Neuroactive ligand-receptor interaction; Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell.
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