Anti-GRIA2 monoclonal antibody, clone FQS6143

Antibody Isotype

IgG

Clone

FQS6143

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Ionotropic Glutamate receptor 2 aa 150-250. The exact sequence is proprietary.

Conjugate

Application Notes

IP: 1/10 - 1/100; WB: 1/1000 - 1/10000; ICC/IF: 1/100 - 1/250.

Alternative Names

GRIA2; glutamate receptor, ionotropic, AMPA 2; GLUR2; glutamate receptor 2; GluA2; GLURB; gluR-2; gluR-B; AMPA-selective glutamate receptor 2; HBGR2; GluR-K2;

Entrez Gene ID

UniProt ID

Antigen Description

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Pathway

Activation of AMPA receptors, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Cocaine addiction, organism-specific biosystem;