Magic™ Anti-GluR2 (Phospho S880, 891) monoclonal antibody, clone FQ030Z

Antibody Isotype

IgG

Clone

FQ030Z

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Ser880/891 of human GluR2 + 3

Conjugate

Application Notes

WB: 1/5000; IP: 1/100; ICC/IF: 1/100 - 1/250

Alternative Names

GRIA2; glutamate receptor, ionotropic, AMPA 2; GLUR2; glutamate receptor 2; GluA2; GLURB; gluR-2; gluR-B; AMPA-selective glutamate receptor 2; HBGR2; GluR-K2;

Entrez Gene ID

UniProt ID

Antigen Description

Ion channels activated by glutamate are typically divided into two classes. Those sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). AMPAR are comprised of four distinct Glutamate Receptor Subunits (GluR1-4) and they play key roles in almost all excitatory neurotransmission in the brain. The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory.

Pathway

Activation of AMPA receptors, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Cocaine addiction, organism-specific biosystem;