Anti-GPC4 monoclonal antibody (CAB-244MH)

Mouse anti-Human GPC4 monoclonal antibody for ELISA, WB, IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
MAFB4044
Species Reactivity
Human
Immunogen
Recombinant human GPC4 (401~529aa) purified from E. Coli.
Conjugate
Unconjugated

Target


Alternative Names
GPC4; glypican 4; glypican-4; glypican proteoglycan 4; K glypican; dJ900E8.1 (glypican 4)
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GPC4 (Glypican 4) is a Protein Coding gene. Diseases associated with GPC4 include gpc4-related simpson-golabi-behmel syndrome type 1 and simpson-golabi-behmel syndrome, type 1. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include heparan sulfate proteoglycan binding. An important paralog of this gene is GPC5. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.
Antigen Description
The glypican (Gpc) family of cell surface heparan sulfate proteoglycans is expressed in a tissue specific and developmentally regulated fashion. Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity). Glypican-4 is a protein that in humans is encoded by the GPC4 gene. 0The function about GPC4 antigen include heparan sulfate proteoglycan binding.
Pathway
Wnt signaling pathway, organism-specific biosystem; Wnt signaling pathway, conserved biosystem.

Citations


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References


Cheong, YK; Ngoh, ZX; et al. Identification of Cell Surface Markers Glypican-4 and CD200 That Differentiate Human Corneal Endothelium From Stromal Fibroblasts. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54:4538-4547(2013).
Geraldes, P; Yamagata, M; et al. Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 48:5750-5755(2007).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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