Anti-GMPS (aa 108-215) polyclonal antibody

Species Reactivity

Human

Immunogen

GMPS (NP_003866, 108 a.a. ~ 215 a.a) partial recombinant protein with GST tag. The sequence is QMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVV ARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSG

Conjugate

Alternative Names

GMPS; guanine monphosphate synthase; GMP synthase [glutamine-hydrolyzing]; GMP synthase; GMP synthetase; MLL/GMPS fusion protein; glutamine amidotransferase; guanine monphosphate synthetase; guanosine 5-monophosphate synthase;

Entrez Gene ID

UniProt ID

Antigen Description

In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.

Pathway

Drug metabolism - other enzymes; Guanine ribonucleotide biosynthesis IMP => Guanine ribonucleotide biosynthesis IMP => Metabolism.