GFAP (AAH41765, 131 a.a. ~ 230 a.a) partial recombinant protein with GST tag. The sequence is TANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKI ESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPD
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Pathway
Neural Crest Differentiation; Signal Transduction; Spinal Cord Injury;
Citations
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