Product Overview
Blocking/Immunizing peptide for anti-GFAP antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Function
integrin binding; structural constituent of cytoskeleton;
Synonyms
GFAP; glial fibrillary acidic protein; FLJ45472; intermediate filament protein; FLJ42474;
Citations
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Baratz, R; Tweedie, D; et al. Transiently lowering tumor necrosis factor-alpha synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice. JOURNAL OF NEUROINFLAMMATION 12:-(2015).
Dobolyi, A; Bago, AG; et al. Localization of SUCLA2 and SUCLG2 subunits of succinyl CoA ligase within the cerebral cortex suggests the absence of matrix substrate-level phosphorylation in glial cells of the human brain. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES 47:33-41(2015).
COA
Certificate of Analysis
