Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.
Pathway
Folate biosynthesis; Metabolism; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; tetrahydrobiopterin biosynthesis I
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