Anti-GBP2 monoclonal antibody (DCABH-646)

Mouse anti-Human GBP2 monoclonal antibody for WB, IHC-P Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
6F21
Species Reactivity
Human
Immunogen
Protein expressed in 293T cell transfected with Hman GBP2 expression vector.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500; IHC-P: 1/50;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
GBP2; guanylate binding protein 2, interferon-inducible; interferon-induced guanylate-binding protein 2; GBP-2; huGBP-2; GTP-binding protein 2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GBP2 (Guanylate Binding Protein 2) is a Protein Coding gene. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP7. This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas.
Antigen Description
Guanylate-binding proteins (GBPs) are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). GBP2 is a GTPase that converts GTP to GDP and GMP. Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Interferon-induced guanylate-binding protein 2 is a protein that in humans is encoded by the GBP2 gene. Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for the guanylate-binding proteins (GBPs). GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). The protein encoded by this gene is a GTPase that converts GTP to GDP and GMP. The function about GBP2 antigen include GTP binding; GTPase activity; nucleotide binding.
Pathway
Cytokine Signaling in Immune system, organism-specific biosystem; Immune System, organism-specific biosystem; Interferon Signaling, organism-specific biosystem; Interferon alpha/beta signaling, organism-specific biosystem; Interferon gamma signaling, organism-specific biosystem.

Citations


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References


Richardson, R; Denis, CL; et al. Mass spectrometric identification of proteins that interact through specific domains of the poly(A) binding protein. MOLECULAR GENETICS AND GENOMICS 287:711-730(2012).
Saban, MR; Hellmich, HL; et al. Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins. BMC CANCER 7:-(2007).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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