Anti-GBA2 monoclonal antibody (DCABH-11686) Made to order

Rabbit anti-Human GBA2 monoclonal antibody for WB, ELISA

View other GBA2 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human GBA2 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
GBA2; glucosidase, beta (bile acid) 2; non-lysosomal glucosylceramidase; AD035; bile acid beta glucosidase; DKFZp762K054
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GBA2 (Glucosylceramidase Beta 2) is a Protein Coding gene. Diseases associated with GBA2 include spastic paraplegia 46, autosomal recessive and spastic paraplegia 46. Among its related pathways are Metabolism and Sphingolipid metabolism. GO annotations related to this gene include beta-glucosidase activity and glucosylceramidase activity. This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism.
Antigen Description
This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism. Spastic paraplegia 46, autosomal recessive (SPG46) [MIM:614409]: A neurodegenerative disorder characterized by onset in childhood of slowly progressive spastic paraplegia and cerebellar signs. Some patients have cognitive impairment, cataracts, and cerebral, cerebellar, and corpus callosum atrophy on brain imaging. Note=The disease is caused by mutations affecting the gene represented in this entry. Non-lysosomal glucosylceramidase is an enzyme that in humans is encoded by the GBA2 gene. It has glucosylceramidase (EC 3. 2. 1. 45) activity. The function about GBA2 antigen include beta-glucosidase activity; glucosylceramidase activity; hydrolase activity, acting on glycosyl bonds.
Pathway
Glycosphingolipid metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Sphingolipid metabolism, organism-specific biosystem.

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Korschen, HG; Yildiz, Y; et al. The Non-lysosomal beta-Glucosidase GBA2 Is a Non-integral Membrane-associated Protein at the Endoplasmic Reticulum (ER) and Golgi. JOURNAL OF BIOLOGICAL CHEMISTRY 288:3381-3393(2013).
Cobucci-Ponzano, B; Aurilia, V; et al. A New Archaeal beta-Glycosidase from Sulfolobus solfataricus SEEDING A NOVEL RETAINING beta-GLYCAN-SPECIFIC GLYCOSIDE HYDROLASE FAMILY ALONG WITH THE HUMAN NON-LYSOSOMAL GLUCOSYLCERAMIDASE GBA2. JOURNAL OF BIOLOGICAL CHEMISTRY 285:20691-20703(2010).

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