Anti-GAS1 polyclonal antibody [Biotin]

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Gas1. Leu40-Ser318 Accession Number P54826

Conjugate

Application Notes

Western Blot: 1 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4166 - DPABY-578

Alternative Names

GAS1; growth arrest-specific 1; growth arrest-specific protein 1; GAS-1; Growth arrest-specific gene-1;

Entrez Gene ID

UniProt ID

Antigen Description

The growth arrest-specific genes are related by their induction following cellular stress. Gas1 is a GPI-linked membrane glycoprotein that blocks entry to S phase cell cycle. Gas1 inhibits cell proliferation, protects endothelial cells from apoptosis, and promotes excitotoxic neuronal death. Gas6 is a vitamin K-dependent protein with a gamma-carboxylated amino terminus (Gla domain), four EGF-like repeats, and C-terminal globulin-like domains. Gas6 is a ligand for the Axl, Dtk, and Mer tyrosine kinase receptors. Gas6 is mitogenic and anti-apoptotic for some cell types and also promotes cell adhesion.

Pathway

FOXM1 transcription factor network; Hedgehog Signaling Pathway; Hedgehog signaling pathway; Signaling events mediated by the Hedgehog family;