Mouse anti-Human FZD6 polyclonal antibody

Species Reactivity

Human

Immunogen

FZD6 (NP_003497, 71 a.a. ~ 181 a.a) partial recombinant protein with GST tag. The sequence is PNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCD ETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQC

Conjugate

Alternative Names

FZD6; frizzled class receptor 6; FZ6; FZ-6; HFZ6; NDNC10; frizzled-6; frizzled homolog 6; frizzled family receptor 6; seven transmembrane helix receptor; frizzled 6, seven transmembrane spanning receptor;

Entrez Gene ID

UniProt ID

Antigen Description

This gene represents a member of the frizzled gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

Pathway

Basal cell carcinoma; Ca2+ pathway; GPCR ligand binding; HTLV-I infection