Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Wen, S; Zhu, HP; et al. Planar Cell Polarity Pathway Genes and Risk for Spina Bifida. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 152A:299-304(2010).
Hughes, KR; Sablitzky, F; et al. Expression Profiling of Wnt Family of Genes in Normal and Inflammatory Bowel Disease Primary Human Intestinal Myofibroblasts and Normal Human Colonic Crypt Epithelial Cells. INFLAMMATORY BOWEL DISEASES 17:213-220(2011).
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