FZD4 (NP_036325, 107 a.a. ~ 206 a.a) partial recombinant protein with GST tag. The sequence is TEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEE VPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGY
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.
Pathway
Asymmetric localization of PCP proteins; Basal cell carcinoma; Class B/2 (Secretin family receptors); HTLV-I infection
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