Specifications
Immunogen
A synthetic peptide of human FZD4 is used for rabbit immunization.
Target
Alternative Names
FZD4; frizzled family receptor 4; EVR1, exudative vitreoretinopathy 1 , frizzled (Drosophila) homolog 4 , frizzled 4, seven transmembrane spanning receptor , frizzled homolog 4 (Drosophila); frizzled-4; CD344; hFz4; frizzled homolog 4; WNT receptor frizzl
Product Background
Antigen Description
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.
Pathway
Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Melanogenesis, organism-specific biosystem.
Citations
Publication ()
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COA
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