Anti-FZD4 monoclonal antibody (DCABH-11639) Made to order

Rabbit anti-Human FZD4 monoclonal antibody for WB, ELISA

View other FZD4 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human FZD4 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
FZD4; frizzled family receptor 4; EVR1, exudative vitreoretinopathy 1 , frizzled (Drosophila) homolog 4 , frizzled 4, seven transmembrane spanning receptor , frizzled homolog 4 (Drosophila); frizzled-4; CD344; hFz4
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FZD4 (Frizzled Class Receptor 4) is a Protein Coding gene. Diseases associated with FZD4 include exudative vitreoretinopathy 1 and exudative vitreoretinopathy. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include G-protein coupled receptor activity and protein heterodimerization activity. An important paralog of this gene is FZD10. This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.
Antigen Description
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. Vitreoretinopathy, exudative 1 (EVR1) [MIM:133780]: A disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. Clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease related abnormality is an arc of avascular retina in the extreme temporal periphery. In many ways the disease resembles retinopathy of prematurity but there is no evidence of prematurity or small birth weight in the patient history. Note=The disease is caused by mutations affecting the gene represented in this entry. Frizzled-4 is a protein that in humans is encoded by the FZD4 gene. FZD4 has also been designated as CD344 (cluster of differentiation 344). Frizzled-4 is the only representative of frizzled family members that binds strongly an additional ligand Norrin that is functionally similar but structurally different from Wingless type proteins. FZD4 signaling induced by Norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear. The function about FZD4 antigen include G-protein coupled receptor activity; PDZ domain binding; PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; cytokine binding; protein binding; protein heterodimerization activity; protein homodimerization activity; receptor activity.
Pathway
Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Melanogenesis, organism-specific biosystem.

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References


Wissmann, C; Wild, PJ; et al. WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. JOURNAL OF PATHOLOGY 201:204-212(2003).
Hunter, DD; Zhang, ML; et al. The extracellular matrix component WIF-1 is expressed during, and can modulate, retinal development. MOLECULAR AND CELLULAR NEUROSCIENCE 27:477-488(2004).

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