Anti-FUT8 monoclonal antibody (DCABH-11633) Made to order

Rabbit anti-Human FUT8 monoclonal antibody for WB, ELISA

View other FUT8 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human FUT8 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
FUT8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); alpha-(1,6)-fucosyltransferase; alpha1-6FucT; glycoprotein 6-alpha-L-fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FUT8 (Fucosyltransferase 8) is a Protein Coding gene. Diseases associated with FUT8 include pancreatic acinar cell adenocarcinoma and recurrent respiratory papillomatosis. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include SH3 domain binding and glycoprotein 6-alpha-L-fucosyltransferase activity. This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants.
Antigen Description
This enzyme belongs to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternatively spliced variants encoding different isoforms have been identified. Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene. 0The function about FUT8 antigen include SH3 domain binding; glycoprotein 6-alpha-L-fucosyltransferase activity; transferase activity, transferring glycosyl groups.
Pathway
Asparagine N-linked glycosylation, organism-specific biosystem; Glycosaminoglycan biosynthesis - keratan sulfate, organism-specific biosystem; Glycosaminoglycan biosynthesis - keratan sulfate, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; N-Glycan biosynthesis, organism-specific biosystem; N-Glycan biosynthesis, conserved biosystem.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Martinez-Duncker, I; Michalski, JC; et al. Activity and tissue distribution of splice variants of alpha 6-fucosyltransferase in human embryogenesis. GLYCOBIOLOGY 14:13-25(2004).
Ito, Y; Miyauchi, A; et al. Expression of alpha 1,6-fucosyltransferase (FUT8) in papillary carcinoma of the thyroid: its linkage to biological aggressiveness and anaplastic transformation. CANCER LETTERS 200:167-172(2003).

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