Specifications
Immunogen
Recombinant fragment within Human FRS2 aa 100-250. The exact sequence is proprietary.Database link: Q8WU20
Applications
Application Notes
WB: 1/1000 - 1/10000; IP: 1/50 - 1/70; Flow Cyt: 1/20;
Target
Alternative Names
FRS2; fibroblast growth factor receptor substrate 2; FRS2A; FRS2alpha; SNT 1; SNT1; FGFR substrate 2; FGFR signalling adaptor; FGFR-signaling adaptor SNT; suc1-associated neurotrophic factor target 1; SNT; SNT-1;
Product Background
Antigen Description
Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Pathway
Downstream signaling of activated FGFR, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; FRS2-mediated cascade, organism-specific biosystem; Frs2-mediated activation, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem; Insulin receptor signalling cascade, organism-specific biosystem;
Citations
Publication ()
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COA
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