Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.
Pathway
AKT phosphorylates targets in the nucleus; Adaptive Immune System; Class I PI3K signaling events mediated by Akt; Disease; Downstream Signaling Events Of B Cell Receptor (BCR); Downstream signal transduction; Downstream signaling of activated FGFR
Citations
Publication ()
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