Synthetic peptide, corresponding to a region within amino acids 50-100 of Human FNBP1L (NP_001157945.1).
Conjugate
Unconjugated
Applications
Application Notes
IP: 2-10 μg/mg lysate.
Target
Alternative Names
FNBP1L; formin binding protein 1-like; TOCA1; C1orf39; formin-binding protein 1-like; toca-1; transducer of Cdc42-dependent actin assembly 1; transducer of Cdc42-dependent actin assembly protein 1;
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles.
Citations
Publication ()
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