Anti-FMO4 monoclonal antibody (DCABH-11587) Made to order

Rabbit anti-Human FMO4 monoclonal antibody for WB, ELISA

View other FMO4 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human FMO4 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
FMO4; flavin containing monooxygenase 4; FMO2; dimethylaniline monooxygenase [N-oxide-forming] 4; FMO 4; dimethylaniline oxidase 4
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FMO4 (Flavin Containing Monooxygenase 4) is a Protein Coding gene. Diseases associated with FMO4 include trimethylaminuria. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include oxidoreductase activity and NADP binding. An important paralog of this gene is FMO2. Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.
Antigen Description
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Dimethylaniline monooxygenase [N-oxide-forming] 4 is an enzyme that in humans is encoded by the FMO4 gene. The function about FMO4 antigen include N,N-dimethylaniline monooxygenase activity; NADP binding; flavin adenine dinucleotide binding; monooxygenase activity.
Pathway
Drug metabolism - cytochrome P45, organism-specific biosystem; Drug metabolism - cytochrome P45, conserved biosystem; nicotine degradation II, organism-specific biosystem.

Citations


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References


Dolphin, CT; Cullingford, TE; et al. Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FM03 and FM04. EUROPEAN JOURNAL OF BIOCHEMISTRY 235:683-689(1996).
Furnes, B; Feng, JN; et al. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. DRUG METABOLISM AND DISPOSITION 31:187-193(2003).

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