Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds.
Pathway
Biological oxidations; Drug metabolism - cytochrome P450; FMO oxidizes nucleophiles; Metabolism; Nicotine metabolism; Phase 1 - Functionalization of compounds;
Citations
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