Full length protein corresponding to Human FMO2 aa 1-471. (NP_001451.1).Sequence: MAKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGVWRFKENVEDG RASIYQSVVTNTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDL LKYIQFQTTVLSVRKCPDFSSSGQWKVVTQSNGKEQSAVFDAVMVCSGHH ILPHIPLKSFPGMERFKGQY
Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive.
Pathway
Biological oxidations; Drug metabolism - cytochrome P450; FMO oxidizes nucleophiles; Metabolism; Phase 1 - Functionalization of compounds; nicotine degradation II;
Citations
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