Anti-FMO2 monoclonal antibody (DCABH-11585) Made to order

Rabbit anti-Human FMO2 monoclonal antibody for WB, ELISA

View other FMO2 antibodies


Host Species
Antibody Isotype
Species Reactivity
A synthetic peptide of human FMO2 is used for rabbit immunization.


Alternative Names
FMO2; flavin containing monooxygenase 2 (non-functional); flavin containing monooxygenase 2; dimethylaniline monooxygenase [N-oxide-forming] 2; FMO 2; FMO 1B1
Entrez Gene ID
UniProt ID

Product Background

Gene summary
FMO2 (Flavin Containing Monooxygenase 2) is a Protein Coding gene. Diseases associated with FMO2 include trimethylaminuria and kabuki syndrome 1. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include oxidoreductase activity and monooxygenase activity. An important paralog of this gene is FMO4. This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants.
Antigen Description
The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, in humans, this enzyme is truncated and is probably rapidly degraded. The protein encoded by this gene represents the truncated form and apparently has no catalytic activity. A functional allele found in African Americans has been reported, but no sequence evidence has been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1. Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive. Dimethylaniline monooxygenase [N-oxide-forming] 2 is an enzyme that in humans is encoded by the FMO2 gene. 0The function about FMO2 antigen include N,N-dimethylaniline monooxygenase activity; NADP binding; flavin adenine dinucleotide binding; monooxygenase activity.
Biological oxidations, organism-specific biosystem; Drug metabolism - cytochrome P45, organism-specific biosystem; Drug metabolism - cytochrome P45, conserved biosystem; FMO oxidizes nucleophiles, organism-specific biosystem; Metabolism, organism-specific biosystem; Phase 1 - Functionalization of compounds, organism-specific biosystem; nicotine degradation II, organism-specific biosystem.


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Hamman, MA; Haehner-Daniels, BD; et al. Stereoselective sulfoxidation of sulindac sulfide by flavin-containing monooxygenases - Comparison of human liver and kidney microsomes and mammalian enzymes. BIOCHEMICAL PHARMACOLOGY 60:7-17(2000).
Krueger, SK; Yueh, MF; et al. Characterization of expressed full-length and truncated FMO2 from rhesus monkey. DRUG METABOLISM AND DISPOSITION 29:693-700(2001).

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